Andrew McPherson

Postdoctoral Fellow
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Email
andrew.mcphersonobfuscate@gmail.com

I am a Postdoctoral Fellow at the Department of Pathology and Laboratory Medicine at University of British Columbia. I am interested in understanding how tumour cells evolve in response to the immune system and cancer treatment, with the aim of improving treatment options. I currently work on the development of computational methods and infrastructure for single cell genome sequencing, with the intention of applying these methods to patient samples and derived xenografts.

Papers

Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer.

ReMixT: clone-specific genomic structure estimation in cancer.

Observing Clonal Dynamics Across Spatiotemporal Axes: A Prelude to Quantitative Fitness Models for Cancer.

E-scape: interactive visualization of single-cell phylogenetics and cancer evolution.

Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes.

Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study.

Clonal genotype and population structure inference from single-cell tumor sequencing.

Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer.

Spatial genomic heterogeneity within localized, multifocal prostate cancer.

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution.

TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data.

Genomic rearrangements involving programmed death ligands are recurrent in primary mediastinal large B-cell lymphoma.

nFuse: discovery of complex genomic rearrangements in cancer using high-throughput sequencing.

The clonal and mutational evolution spectrum of primary triple-negative breast cancers.

14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma.

deFuse: an algorithm for gene fusion discovery in tumor RNA-Seq data.

Comrad: detection of expressed rearrangements by integrated analysis of RNA-Seq and low coverage genome sequence data.

MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers.

ARID1A mutations in endometriosis-associated ovarian carcinomas.