Ali Bashashati

Staff Scientist
Email
abashashobfuscate@bccrc.ca

I received my B.Sc. degree in Electrical Engineering from Sharif University of Technology (SUT), Iran in 2000, the M.Sc. degree in Biomedical Engineering from Amirkabir University of Technology (Tehran polytechnic), Iran in 2002, and the Ph.D. degree in Electrical & Computer Engineering from University of British Columbia, Canada in 2007. Currently, I am a Staff Scientist and Director of Operation of Computational Biology Group at the Molecular Oncology Department of the British Columbia Cancer Agency Previous to this, I was an Eli-Lilly Canada research fellow and used to hold both the NSERC & MSFHR post-doctoral fellowships in the Molecular Oncology and Terry Fox Laboratory of the British Columbia Cancer Research Center in Vancouver, Canada.

Papers

LINE-1 retrotransposon-mediated DNA transductions in endometriosis associated ovarian cancers.

The driver landscape of sporadic chordoma.

Kronos: a workflow assembler for genome analytics and informatics.

Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes.

Genetic profiling of MYC and BCL2 in diffuse large B-cell lymphoma determines cell-of-origin-specific clinical impact.

CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion.

Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study.

Robust high-performance nanoliter-volume single-cell multiple displacement amplification on planar substrates.

Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer.

Synchronous Endometrial and Ovarian Carcinomas: Evidence of Clonality.

The genomic landscape of epithelioid sarcoma cell lines and tumours.

Systematic analysis of somatic mutations impacting gene expression in 12 tumour types.

Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden.

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution.

An RCOR1 loss-associated gene expression signature identifies a prognostically significant DLBCL subgroup.

TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data.

DriverNet: uncovering the impact of somatic driver mutations on transcriptional networks in cancer.

Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling.

Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer.

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.

The clonal and mutational evolution spectrum of primary triple-negative breast cancers.

JointSNVMix: a probabilistic model for accurate detection of somatic mutations in normal/tumour paired next-generation sequencing data.

Feature-based classifiers for somatic mutation detection in tumour-normal paired sequencing data.